TranshumanGene Science

TranshumanGene research program

TranshumanGene explores probabilistic genomics, AI-generated mutation modeling, virtual molecules, microRNA hypotheses and computational strategies for viruses, antimicrobial resistance, cancer and genome-scale interpretation.

The program connects biology and computation: generative models propose biological possibilities; probabilistic filters prioritize them; scientific validation remains the decisive gate.

TranshumanGene

PROBABILISTIC GENOMICS

MASSIVE AI-GENERATED MUTATIONS THROUGH PREDICTIVE MODELS

GENERATION OF VIRTUAL MOLECULES AND MicroRNA FOR FIGHTING VIRUSES, AMR, CANCERS, ENHANCING HUMAN GENOMES, DISCOVERING AND VALIDATING DRUGS

TRANSHUMANGENE

PROBABILISTIC GENOMICS

MASSIVE AI GENERATED MUTATIONS THROUGH PREDICTIVE MODELS

GENERATION OF VIRTUAL MOLECULES AND MicroRNA FOR FIGHTING VIRUSES, AMR, CANCERS, ENHANCING HUMAN GENOMES, DISCOVERING AND VALIDATING DRUGS

TRANSHUMANGENE

Mental health

Our key publications

1: Sleep Quality and Physical Activity as Predictors of Mental Wellbeing Variance in Older Adults during COVID-19 Lockdown: ECLB COVID-19 International Online Survey

Khaled Trabelsi, Achraf Ammar, Liwa Masmoudi, Omar Boukhris, Hamdi Chtourou, Bassem Bouaziz, Michael Brach, Ellen Bentlage, Daniella How, Mona Ahmed, Patrick Mueller, Notger Mueller, Hsen Hsouna, Yousri Elghoul, Mohamed Romdhani, Omar Hammouda, Laisa Liane Paineiras-Domingos, Annemarie Braakman-Jansen, Christian Wrede, Sofia Bastoni, Carlos Soares Pernambuco, Leonardo Jose Mataruna-Dos-Santos, Morteza Taheri, Khadijeh Irandoust, Nicola L. Bragazzi, Jana Strahler, Jad Adrian Washif, Albina Andreeva, Stephen J. Bailey, Jarred Acton, Emma Mitchell, Nicholas T. Bott, Faiez Gargouri, Lotfi Chaari, Hadj Batatia, Samira C. Khoshnami, Evangelia Samara, Vasiliki Zisi, Parasanth Sankar, Waseem N. Ahmed, Gamal Mohamed Ali, Osama Abdelkarim, Mohamed Jarraya, Kais El Abed, Wassim Moalla, Nafaa Souissi, Asma Aloui, Nizar Souissi, Lisette Van Gemert-Pijnen, Bryan L. Riemann, Laurel Riemann, Jan Delhey, Jonathan Gómez-Raja, Monique Epstein, Robbert Sanderman, Sebastian Schulz, Achim Jerg, Ramzi Al-Horani, Taysir Mansi, Ismail Dergaa, Mohamed Jmail, Fernando Barbosa, Fernando Ferreira-Santos, Boštjan Šimunič, Rado Pišot, Saša Pišot, Andrea Gaggioli, Jürgen Steinacker, Piotr Zmijewski, Christian Apfelbacher, Jordan M. Glenn, Aïmen Khacharem, Cain C.T. Clark, Helmi Ben Saad, Karim Chamari, Tarak Driss, Anita Hoekelmann, on behalf of the ECLB-COVID19 Consortium

Int J Environ Res Public Health. 2021 Apr; 18(8): 4329. Published online 2021 Apr 19. doi: 10.3390/ijerph18084329

PMCID: PMC8073845

2: The Effect of Mental Fatigue on Cognitive and Aerobic Performance in Adolescent Active Endurance Athletes: Insights from a Randomized Counterbalanced, Cross-Over Trial

Maamer Slimani, Hela Znazen, Nicola Luigi Bragazzi, Mohamed Sami Zguira, David Tod

J Clin Med. 2018 Dec; 7(12): 510. Published online 2018 Dec 3. doi: 10.3390/jcm7120510 PMCID: PMC6306934

3: Effects of home confinement on mental health and lifestyle behaviours during the COVID-19 outbreak: insights from the ECLB-COVID19 multicentre study

Achraf Ammar, Khaled Trabelsi, Michael Brach, Hamdi Chtourou, Omar Boukhris, Liwa Masmoudi, Bassem Bouaziz, Ellen Bentlage, Daniella How, Mona Ahmed, Patrick Mueller, Notger Mueller, Omar Hammouda, Laisa Liane Paineiras-Domingos, Annemarie Braakman-jansen, Christian Wrede, Sophia Bastoni, Carlos Soares Pernambuco, Leonardo Mataruna, Morteza Taheri, Khadijeh Irandoust, Aïmen Khacharem, Nicola L Bragazzi, Jana Strahler, Jad Adrian, Albina Andreeva, Jordan M Glenn, Nicholas T Bott, Faiez Gargouri, Lotfi Chaari, Hadj Batatia, Samira C khoshnami, Evangelia Samara, Vasiliki Zisi, Parasanth Sankar, Waseem N Ahmed, Gamal Mohamed Ali, Osama Abdelkarim, Mohamed Jarraya, Kais El Abed, Wassim Moalla, Mohamed Romdhani, Asma Aloui, Nizar Souissi, Pijnen Lisette Van Gemert, Bryan L Riemann, Laurel Riemann, Jan Delhey, Jonathan Gómez- Raja, Monique Epstein, Robbert Sanderman, Sebastian Schulz, Achim Jerg, Ramzi Al-Horani, Taysir Mansi, Mohamed Jmail, Fernando Barbosa, Fernando Ferreira-Santos, Boštjan Šimunič, Rado Pišot, Saša Pišot, Andrea Gaggioli, Piotr Zmijewski, Stephen J Bailey, Jürgen Steinacker, Karim Chamari, Tarak Driss, Anita Hoekelmann

Biol Sport. 2021 Mar; 38(1): 9-21. Published online 2020 Aug 3. doi: 10.5114/biolsport.2020.96857 PMCID: PMC7996377

4: Searching the Internet for psychiatric disorders among Arab and Jewish Israelis: insights from a comprehensive infodemiological survey

Mohammad Adawi, Howard Amital, Mahmud Mahamid, Daniela Amital, Bishara Bisharat, Naim Mahroum, Kassem Sharif, Adi Guy, Amin Adawi, Hussein Mahagna, Arsalan Abu Much, Samaa Watad, Nicola Luigi Bragazzi, Abdulla Watad

PeerJ. 2018; 6: e4507. Published online 2018 Mar 14. doi: 10.7717/peerj.4507 PMCID: PMC5857171

5: Psychological consequences of COVID-19 home confinement: The ECLB-COVID19 multicenter study

Achraf Ammar, Patrick Mueller, Khaled Trabelsi, Hamdi Chtourou, Omar Boukhris, Liwa Masmoudi, Bassem Bouaziz, Michael Brach, Marlen Schmicker, Ellen Bentlage, Daniella How, Mona Ahmed, Asma Aloui, Omar Hammouda, Laisa Liane Paineiras-Domingos, Annemarie Braakman-jansen, Christian Wrede, Sophia Bastoni, Carlos Soares Pernambuco, Leonardo Jose Mataruna-Dos-Santos, Morteza Taheri, Khadijeh Irandoust, Aïmen Khacharem, Nicola L. Bragazzi, Jad Adrian Washif, Jordan M. Glenn, Nicholas T. Bott, Faiez Gargouri, Lotfi Chaari, Hadj Batatia, Samira C. khoshnami, Evangelia Samara, Vasiliki Zisi, Parasanth Sankar, Waseem N. Ahmed, Gamal Mohamed Ali, Osama Abdelkarim, Mohamed Jarraya, Kais El Abed, Mohamed Romdhani, Nizar Souissi, Lisette Van Gemert-Pijnen, Stephen J. Bailey, Wassim Moalla, Jonathan Gómez-Raja, Monique Epstein, Robbert Sanderman, Sebastian Schulz, Achim Jerg, Ramzi Al-Horani, Taysir Mansi, Mohamed Jmail, Fernando Barbosa, Fernando Ferreira-Santos, Boštjan Šimunič, Rado Pišot, Andrea Gaggioli, Piotr Zmijewski, Jürgen M. Steinacker, Jana Strahler, Laurel Riemann, Bryan L. Riemann, Notger Mueller, Karim Chamari, Tarak Driss, Anita Hoekelmann, for the ECLB-COVID19 Consortium

PLoS One. 2020; 15(11): e0240204. Published online 2020 Nov 5. doi: 10.1371/journal.pone.0240204 PMCID: PMC7643949

6: Development of the 12-Item Social Media Disinformation Scale and its Association With Social Media Addiction and Mental Health Related to COVID-19 in Tunisia: Survey-Based Pilot Case Study

Noomen Guelmami, Maher Ben Khalifa, Nasr Chalghaf, Jude Dzevela Kong, Tannoubi Amayra, Jianhong Wu, Fairouz Azaiez, Nicola Luigi Bragazzi

JMIR Form Res. 2021 Jun; 5(6): e27280. Published online 2021 Jun 9. doi: 10.2196/27280 PMCID: PMC8191730

7: Thirty Years of Human Rights Study in the Web of Science Database (1990-2020)

Priscilla Paola Severo, Leonardo B. Furstenau, Michele Kremer Sott, Danielli Cossul, Mariluza Sott Bender, Nicola Luigi Bragazzi

Int J Environ Res Public Health. 2021 Feb; 18(4): 2131. Published online 2021 Feb 22. doi: 10.3390/ijerph18042131

PMCID: PMC7926733

8: Investigating Aggressive Styles and Defense Mechanisms in Bipolar Patients and in their Parents

Nicola Luigi Bragazzi, Franca Pezzoni, Giovanni Del Puente

Health Psychol Res. 2014 Nov 6; 2(3): 1546. Published online 2014 Oct 21. doi: 10.4081/hpr.2014.1546 PMCID: PMC4768587

9: The Effect of Spatial Ability in Learning From Static and Dynamic Visualizations: A Moderation Analysis in 6- Year-Old Children

Anis Ben Chikha, Aïmen Khacharem, Khaled Trabelsi, Nicola Luigi Bragazzi

Front Psychol. 2021; 12: 583968. Published online 2021 Jun 18. doi: 10.3389/fpsyg.2021.583968

PMCID: PMC8249578

10: Data concerning the impact of mental fatigue on vigor as measured with the Brunel Mood Scale (BRUMS) in both physically active and trained subjects: A mini meta-analysis

Maamer Slimani, Nicola Luigi Bragazzi

Data Brief. 2017 Aug; 13: 655-660. Published online 2017 Jul 5. doi: 10.1016/j.dib.2017.06.056 PMCID: PMC5503827

11: Empowering patients of a mental rehabilitation center in a low-resource context: a Moroccan experience as a case study

Hicham Khabbache, Abdelhak Jebbar, Nadia Rania, Marie-Chantal Doucet, Ali Assad Watfa, Joël Candau, Mariano Martini, Anna Siri, Francesco Brigo, Nicola Luigi Bragazzi

Psychol Res Behav Manag. 2017; 10: 103-108. Published online 2017 Apr 10. doi: 10.2147/PRBM.S117456 PMCID: PMC5391834

12: Anxiety, Post-Traumatic Stress, and Burnout in Health Professionals during the COVID-19 Pandemic: Comparing Mental Health Professionals and Other Healthcare Workers

Isabella Giulia Franzoi, Antonella Granieri, Maria Domenica Sauta, Monica Agnesone, Marco Gonella, Roberto Cavallo, Piergiorgio Lochner, Nicola Luigi Bragazzi, Andrea Naldi

Healthcare (Basel) 2021 Jun; 9(6): 635. Published online 2021 May 27. doi: 10.3390/healthcare9060635 PMCID: PMC8229458

13: Effects of Motor Mental Imagery Training on Tennis Service Performance during the Ramadan Fasting: A Randomized, Controlled Trial

Sofien Fekih, Mohamed Sami Zguira, Abdessalem Koubaa, Liwa Masmoudi, Nicola Luigi Bragazzi, Mohamed Jarraya

Nutrients. 2020 Apr; 12(4): 1035. Published online 2020 Apr 9. doi: 10.3390/nu12041035 PMCID: PMC7231086

14: SARS/MERS/SARS-CoV-2 Outbreaks and Burnout Syndrome among Healthcare Workers. An Umbrella Systematic Review

Nicola Magnavita, Francesco Chirico, Sergio Garbarino, Nicola Luigi Bragazzi, Emiliano Santacroce, Salvatore Zaffina

Int J Environ Res Public Health. 2021 Apr; 18(8): 4361. Published online 2021 Apr 20. doi: 10.3390/ijerph18084361

PMCID: PMC8072681

15: Learning a Motor Skill from Video and Static Pictures in Physical Education Students-Effects on Technical Performances, Motivation and Cognitive Load

Cyrine H'mida, Olivier Degrenne, Nafaa Souissi, Ghazi Rekik, Khaled Trabelsi, Mohamed Jarraya, Nicola Luigi Bragazzi, Aïmen Khacharem

Int J Environ Res Public Health. 2020 Dec; 17(23): 9067. Published online 2020 Dec 4. doi: 10.3390/ijerph17239067

PMCID: PMC7730545

16: Sleep Patterns, Alertness, Dietary Intake, Muscle Soreness, Fatigue, and Mental Stress Recorded before, during and after Ramadan Observance

Omar Boukhris, Khaled Trabelsi, Roy Jesse Shephard, Hsen Hsouna, Raouf Abdessalem, Lassaad Chtourou, Achraf Ammar, Nicola Luigi Bragazzi, Hamdi Chtourou

Sports (Basel) 2019 May; 7(5): 118. Published online 2019 May 17. doi: 10.3390/sports7050118 PMCID: PMC6571812

17: COVID-19 Pandemic and Physical Exercise: Lessons Learnt for Confined Communities

Amine Ghram, Nicola Luigi Bragazzi, Walid Briki, Yaser Jenab, Mehdi Khaled, Monoem Haddad, Karim Chamari Front Psychol. 2021; 12: 618585. Published online 2021 May 5. doi: 10.3389/fpsyg.2021.618585

PMCID: PMC8131539

18: Staying Physically Active During the Quarantine and Self-Isolation Period for Controlling and Mitigating the COVID-19 Pandemic: A Systematic Overview of the Literature

Hamdi Chtourou, Khaled Trabelsi, Cyrine H'mida, Omar Boukhris, Jordan M. Glenn, Michael Brach, Ellen Bentlage, Nick Bott, Roy Jesse Shephard, Achraf Ammar, Nicola Luigi Bragazzi

Front Psychol. 2020; 11: 1708. Published online 2020 Aug 19. doi: 10.3389/fpsyg.2020.01708 PMCID: PMC7466737

19: Depression among Iranian nurses: A systematic review and meta-analysis

Sahar Sadat Saeedi Shahri, Ahmad Ghashghaee, Masoud Behzadifar, Nicola Luigi Bragazzi, Meysam Behzadifar, Nasrin Mousavinejad, Mozhgan Sadat Ghaemmohamadi, Faezeh Ebadi, Hesam Seyedin

Med J Islam Repub Iran. 2017; 31: 130. Published online 2017 Dec 25. doi: 10.14196/mjiri.31.130 PMCID: PMC6014776

20: General health status in Iranian diabetic patients assessed by short-form-36 questionnaire: a systematic review and meta-analysis

Masoud Behzadifar, Rahim Sohrabi, Roghayeh Mohammadibakhsh, Morteza Salemi, Sharare Taheri Moghadam, Masood Taheri Mirghaedm, Meysam Behzadifar, Hamid Reza Baradaran, Nicola Luigi Bragazzi

BMC Endocr Disord. 2018; 18: 34. Published online 2018 May 31. doi: 10.1186/s12902-018-0262-2 PMCID: PMC5984362

21: Health-related quality of life among healthy elderly Iranians: a systematic review and meta-analysis of the literature

Sogand Tourani, Masoud Behzadifar, Mariano Martini, Aidin Aryankhesal, Masood Taheri Mirghaed, Morteza Salemi, Meysam Behzadifar, Nicola Luigi Bragazzi

Health Qual Life Outcomes. 2018; 16: 18. Published online 2018 Jan 18. doi: 10.1186/s12955-018-0845-7

PMCID: PMC5774099

22: Dose-Response Relationship between Endurance Training Prescription Variables and Increases in Aerobic Performance of Healthy and Unhealthy Middle and Very Old Individuals Aged 70 Years and Older: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sarah Cheour, Chouaib Cheour, Nicola Luigi Bragazzi, Liye Zou, Armin H. Paravlic, Maamer Slimani, Foued Cheour Life (Basel) 2021 Feb; 11(2): 121. Published online 2021 Feb 5. doi: 10.3390/life11020121

PMCID: PMC7914556

23: The Relationship between Cognitive Function, Lifestyle Behaviours and Perception of Stress during the COVID-19 Induced Confinement: Insights from Correlational and Mediation Analyses

Hela Znazen, Maamer Slimani, Nicola Luigi Bragazzi, David Tod

Int J Environ Res Public Health. 2021 Mar; 18(6): 3194. Published online 2021 Mar 19. doi: 10.3390/ijerph18063194

PMCID: PMC8003540

24: The COVID-19 pandemic: how to maintain a healthy immune system during the lockdown - a multidisciplinary approach with special focus on athletes

Narimen Yousfi, Nicola Luigi Bragazzi, Walid Briki, Piotr Zmijewski, Karim Chamari

Biol Sport. 2020 Sep; 37(3): 211-216. Published online 2020 May 19. doi: 10.5114/biolsport.2020.95125 PMCID: PMC7433333

25: The psychological impact of COVID-19 Pandemic on the population of Bahrain

Ali AlSalman, Hajar Mubarak, Majed Aljabal, Mahmood Abdulnabi, Alhareth Ishaq, Adel Yusuf, Nicola Bragazzi, Haitham Jahrami

Acta Biomed. 2020; 91(4): e2020131. Published online 2020 Oct 26. doi: 10.23750/abm.v91i4.10336 PMCID: PMC7927468

26: A proposal for including nomophobia in the new DSM-V

Nicola Luigi Bragazzi, Giovanni Del Puente

Psychol Res Behav Manag. 2014; 7: 155-160. Published online 2014 May 16. doi: 10.2147/PRBM.S41386 PMCID: PMC4036142

27: Rethinking psychiatry with OMICS science in the age of personalized P5 medicine: ready for psychiatome?

Nicola Luigi Bragazzi

Philos Ethics Humanit Med. 2013; 8: 4. Published online 2013 Jul 12. doi: 10.1186/1747-5341-8-4 PMCID: PMC4120773

28: 100 Years of Scientific Evolution of Work and Organizational Psychology: A Bibliometric Network Analysis From 1919 to 2019

Michele K. Sott, Mariluza S. Bender, Leonardo B. Furstenau, Laura M. Machado, Manuel J. Cobo, Nicola L. Bragazzi

Front Psychol. 2020; 11: 598676. Published online 2020 Dec 3. doi: 10.3389/fpsyg.2020.598676 PMCID: PMC7744602

29: Chronic Kidney Disease, Spirituality and Religiosity: A Systematic Overview with the List of Eligible Studies

Nicola Luigi Bragazzi, Giovanni Del Puente

Health Psychol Res. 2013 Apr 18; 1(2): e26. Published online 2013 Aug 7. doi: 10.4081/hpr.2013.e26 PMCID: PMC4768585

30: Moderation Effect of Physical Activity on the Relationship Between Fear of COVID-19 and General Distress: A Pilot Case Study in Arabic Countries

Tareq A. Alsalhe, Sulaiman O. Aljaloud, Nasr Chalghaf, Noomen Guelmami, Dallal W. Alhazza, Fairouz Azaiez, Nicola Luigi Bragazzi

Front Psychol. 2020; 11: 570085. Published online 2020 Sep 23. doi: 10.3389/fpsyg.2020.570085 PMCID: PMC7539623

31: Diet-Related Inflammation is Associated with Major Depressive Disorder in Bahraini Adults: Results of a Case-Control Study Using the Dietary Inflammatory Index

Wen Chen, Mo'ez Al-Islam E Faris, Nicola Luigi Bragazzi, Haifa M S AlGahtani, Zahra Saif, Ahmed Jahrami, Nitin Shivappa, James R Hebert, Haitham Jahrami

J Inflamm Res. 2021; 14: 1437-1445. Published online 2021 Apr 15. doi: 10.2147/JIR.S306315 PMCID: PMC8055288

32: COVID-19 Home Confinement Negatively Impacts Social Participation and Life Satisfaction: A Worldwide Multicenter Study

Achraf Ammar, Hamdi Chtourou, Omar Boukhris, Khaled Trabelsi, Liwa Masmoudi, Michael Brach, Bassem Bouaziz, Ellen Bentlage, Daniella How, Mona Ahmed, Patrick Mueller, Notger Mueller, Hsen Hsouna, Asma Aloui, Omar Hammouda, Laisa Liane Paineiras-Domingos, Annemarie Braakman-Jansen, Christian Wrede, Sophia Bastoni, Carlos Soares Pernambuco, Leonardo Jose Mataruna-Dos-Santos, Morteza Taheri, Khadijeh Irandoust, Aïmen Khacharem, Nicola L. Bragazzi, Jana Strahler, Jad Adrian Washif, Albina Andreeva, Samira C. khoshnami, Evangelia Samara, Vasiliki Zisi, Parasanth Sankar, Waseem N. Ahmed, Mohamed Romdhani, Jan Delhey, Stephen

J. Bailey, Nicholas T. Bott, Faiez Gargouri, Lotfi Chaari, Hadj Batatia, Gamal Mohamed Ali, Osama Abdelkarim, Mohamed Jarraya, Kais El Abed, Nizar Souissi, Lisette Van Gemert-Pijnen, Bryan L. Riemann, Laurel Riemann, Wassim Moalla, Jonathan Gómez-Raja, Monique Epstein, Robbert Sanderman, Sebastian Schulz, Achim Jerg, Ramzi Al-Horani, Taiysir Mansi, Mohamed Jmail, Fernando Barbosa, Fernando Ferreira-Santos, Boštjan Šimunič, Rado Pišot, Saša Pišot, Andrea Gaggioli, Piotr Zmijewski, Christian Apfelbacher, Jürgen Steinacker, Helmi Ben Saad, Jordan M. Glenn, Karim Chamari, Tarak Driss, Anita Hoekelmann, on behalf of the ECLB-COVID19 Consortium

Int J Environ Res Public Health. 2020 Sep; 17(17): 6237. Published online 2020 Aug 27. doi: 10.3390/ijerph17176237

PMCID: PMC7503681

doi: 10.3390/ijerph15061121

33: Sleep Quality among Police Officers: Implications and Insights from a Systematic Review and Meta- Analysis of the Literature

Sergio Garbarino, Ottavia Guglielmi, Matteo Puntoni, Nicola Luigi Bragazzi, Nicola Magnavita Int J Environ Res Public Health. 2019 Mar; 16(5): 885. Published online 2019 Mar 11.

doi: 10.3390/ijerph16050885

PMCID: PMC6427768

34: Vitamin D Doses from Solar Ultraviolet and Dietary Intakes in Patients with Depression: Results of a Case- Control Study

Haitham Jahrami, Nicola Luigi Bragazzi, William Burgess Grant, Hala Shafeeq Mohamed AlFarra, Wafa Shafeeq Mohamed AlFara, Shahla Mashalla, Zahra Saif

Nutrients. 2020 Sep; 12(9): 2587. Published online 2020 Aug 26. doi: 10.3390/nu12092587 PMCID: PMC7551208

35: The Impact of a Motor Imagery-Based Training Program on Agility, Speed, and Reaction Time in a Sample of Young Tennis Athletes during Ramadan Fasting: Insights and Implications from a Randomized, Controlled Experimental Trial

Sofien Fekih, Mohamed Sami Zguira, Abdessalem Koubaa, Imed Ghariani, Hamdi Zguira, Nicola Luigi Bragazzi, Mohamed Jarraya

Nutrients. 2020 Nov; 12(11): 3306. Published online 2020 Oct 29. doi: 10.3390/nu12113306 PMCID: PMC7692860

36: Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB- COVID19 International Online Survey

Achraf Ammar, Michael Brach, Khaled Trabelsi, Hamdi Chtourou, Omar Boukhris, Liwa Masmoudi, Bassem Bouaziz, Ellen Bentlage, Daniella How, Mona Ahmed, Patrick Müller, Notger Müller, Asma Aloui, Omar Hammouda, Laisa Liane Paineiras-Domingos, Annemarie Braakman-Jansen, Christian Wrede, Sofia Bastoni, Carlos Soares Pernambuco, Leonardo Mataruna, Morteza Taheri, Khadijeh Irandoust, Aïmen Khacharem, Nicola

L. Bragazzi, Karim Chamari, Jordan M. Glenn, Nicholas T. Bott, Faiez Gargouri, Lotfi Chaari, Hadj Batatia, Gamal Mohamed Ali, Osama Abdelkarim, Mohamed Jarraya, Kais El Abed, Nizar Souissi, Lisette Van Gemert-Pijnen,

Bryan L. Riemann, Laurel Riemann, Wassim Moalla, Jonathan Gómez-Raja, Monique Epstein, Robbert Sanderman, Sebastian V. W. Schulz, Achim Jerg, Ramzi Al-Horani, Taiysir Mansi, Mohamed Jmail, Fernando Barbosa, Fernando Ferreira-Santos, Boštjan Šimunič, Rado Pišot, Andrea Gaggioli, Stephen J. Bailey, Jürgen M. Steinacker, Tarak Driss, Anita Hoekelmann, On Behalf of the ECLB-COVID19 Consortium

Nutrients. 2020 Jun; 12(6): 1583. Published online 2020 May 28. doi: 10.3390/nu12061583 PMCID: PMC7352706

37: A Bibliometric Network Analysis of Coronavirus during the First Eight Months of COVID-19 in 2020

Leonardo B. Furstenau, Bruna Rabaioli, Michele Kremer Sott, Danielli Cossul, Mariluza Sott Bender, Eduardo Moreno Júdice De Mattos Farina, Fabiano Novaes Barcellos Filho, Priscilla Paola Severo, Michael S. Dohan, Nicola Luigi Bragazzi

Int J Environ Res Public Health. 2021 Feb; 18(3): 952. Published online 2021 Jan 22. doi: 10.3390/ijerph18030952 PMCID: PMC7908247

38: Effects of Home Confinement on the Intensity of Physical Activity during the COVID-19 Outbreak in Team Handball According to Country, Gender, Competition Level, and Playing Position: A Worldwide Study

Souhail Hermassi, El Ghali Bouhafs, Nicola Luigi Bragazzi, Shiro Ichimura, Khaled E. Alsharji, Lawrence D. Hayes, René Schwesig

Int J Environ Res Public Health. 2021 Apr; 18(8): 4050. Published online 2021 Apr 12. doi: 10.3390/ijerph18084050

PMCID: PMC8069346

39: COVID-19 pandemic-related anxiety, distress and burnout: prevalence and associated factors in healthcare workers of North-West Italy

Andrea Naldi, Fabrizio Vallelonga, Alessandra Di Liberto, Roberto Cavallo, Monica Agnesone, Marco Gonella, Maria Domenica Sauta, Piergiorgio Lochner, Giacomo Tondo, Nicola Luigi Bragazzi, Rossana Botto, Paolo Leombruni

BJPsych Open. 2021 Jan; 7(1): e27. Published online 2021 Jan 7. doi: 10.1192/bjo.2020.161 PMCID: PMC7844147

40: Panic attacks and possession by djinns: lessons from ethnopsychiatry

Nicola Luigi Bragazzi, Giovanni Del Puente

Psychol Res Behav Manag. 2012; 5: 185-190. Published online 2012 Dec 20. doi: 10.2147/PRBM.S37714 PMCID: PMC3533684

41: Sleep Disturbances Rate among Medical and Allied Health Professions Students in Iran: Implications from a Systematic Review and Meta-Analysis of the Literature

Mojtaba Khaksarian, Masoud Behzadifar, Meysam Behzadifar, Firuzeh Jahanpanah, Ottavia Guglielmi, Sergio Garbarino, Paola Lanteri, Tania Simona Re, Riccardo Zerbetto, Juan José Maldonado Briegas, Matteo Riccò, Nicola Luigi Bragazzi

Int J Environ Res Public Health. 2020 Feb; 17(3): 1011. Published online 2020 Feb 5. doi: 10.3390/ijerph17031011

PMCID: PMC7037918

42: Why P6 Medicine Needs Clinical Psychology and a Trans-Cultural Approach

Nicola Luigi Bragazzi, Giovanni Del Puente

Health Psychol Res. 2013 Jan 2; 1(1): e5. Published online 2013 Jan 28. doi: 10.4081/hpr.2013.e5 PMCID: PMC4768607

43: Patterns of Harmful Alcohol Consumption among Truck Drivers: Implications for Occupational Health and Work Safety from a Systematic Review and Meta-Analysis

Nicola Luigi Bragazzi, Guglielmo Dini, Alessandra Toletone, Alborz Rahmani, Alfredo Montecucco, Emanuela Massa, Alessia Manca, Ottavia Guglielmi, Sergio Garbarino, Nicoletta Debarbieri, Paolo Durando

Int J Environ Res Public Health. 2018 Jun; 15(6): 1121. Published online 2018 May 30.

Hamdi Chtourou, Khaled Trabelsi, Achraf Ammar, Roy Jesse Shephard, Nicola Luigi Bragazzi

PMCID: PMC6025607

44: Low birth weight in Iran: Implications from a systematic review of the literature and meta-analysis in the period 1999-2017

Faezeh Ebadi, Ahmad Ghashghaee, Nicola Luigi Bragazzi, Mariano Martini, Razieh Sepehrian, Mozhgan sadat Ghaemmohamadi, Sahar Sadat Saeedi Shahri, Meysam Behzadifar, Aidin Aryankhesal, Masoud Behzadifar

Med J Islam Repub Iran. 2018; 32: 13. Published online 2018 Feb 13. doi: 10.14196/mjiri.32.13 PMCID: PMC6108244

45: Ramadan Fasting Improves Body Composition without Exacerbating Depression in Males with Diagnosed Major Depressive Disorders

Haitham Jahrami, Ahmed S. BaHammam, Eman Ahmed Haji, Nicola L. Bragazzi, Ihab Rakha, Amani Alsabbagh, Boya Nugraha, Stefan M. Pasiakos

Nutrients. 2021 Aug; 13(8): 2718. Published online 2021 Aug 7. doi: 10.3390/nu13082718 PMCID: PMC8398343

46: The Relationship Between Physical Activity and Quality of Life During the Confinement Induced by COVID- 19 Outbreak: A Pilot Study in Tunisia

Maamer Slimani, Armin Paravlic, Faten Mbarek, Nicola L. Bragazzi, David Tod

Front Psychol. 2020; 11: 1882. Published online 2020 Aug 7. doi: 10.3389/fpsyg.2020.01882 PMCID: PMC7427614

47: Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics)

Vural Özdemir, Laszlo Endrenyi, Şükrü Aynacıoğlu, Nicola Luigi Bragazzi, Collet Dandara, Edward S. Dove, Lynnette R. Ferguson, Christy Jo Geraci, Ernst Hafen, Belgin Eroğlu Kesim, Eugene Kolker, Edmund J.D. Lee, Adrian LLerena, Muradiye Nacak, Kazutaka Shimoda, Toshiyuki Someya, Sanjeeva Srivastava, Brian Tomlinson, Effy Vayena, Louise Warnich, Ümit Yaşar

OMICS. 2014 Apr 1; 18(4): 211-221. doi: 10.1089/omi.2014.0029 PMCID: PMC3976589

48: Understanding the Missing Link Between Musical Attitudes, Preferences and Psychological Profiles: Music as Auto-Medication and Self-Administered Therapy? Implications for Music Therapy

Nicola Luigi Bragazzi, Giorgio Ratto, Nicola Dalle Luche, Tiziana Canfori, Claudio Proietti, Giovanni Del Puente Health Psychol Res. 2015 Nov 30; 3(3): 1545. Published online 2015 Nov 30. doi: 10.4081/hpr.2015.1545 PMCID: PMC4768526

49: The Effect of Physical Activity on Cognitive Performance in an Italian Elementary School: Insights From a Pilot Study Using Structural Equation Modeling

Johnny Padulo, Nicola Luigi Bragazzi, Andrea De Giorgio, Zoran Grgantov, Sebastiano Prato, Luca Paolo Ardigò Front Physiol. 2019; 10: 202. Published online 2019 Mar 5. doi: 10.3389/fphys.2019.00202

PMCID: PMC6412095

50: Effect of a Warm-Up Protocol with and without Facemask-Use against COVID-19 on Cognitive Function: A Pilot, Randomized Counterbalanced, Cross-Sectional Study

Maamer Slimani, Bianca Miarka, Hela Znazen, Wassim Moalla, Amri Hammami, Armin Paravlic, Nicola Luigi Bragazzi

Int J Environ Res Public Health. 2021 Jun; 18(11): 5885. Published online 2021 May 30. doi: 10.3390/ijerph18115885

PMCID: PMC8197822

51: Data Mining in Healthcare: Applying Strategic Intelligence Techniques to Depict 25 Years of Research Development

Maikel Luis Kolling, Leonardo B. Furstenau, Michele Kremer Sott, Bruna Rabaioli, Pedro Henrique Ulmi, Nicola Luigi Bragazzi, Leonel Pablo Carvalho Tedesco

Int J Environ Res Public Health. 2021 Mar; 18(6): 3099. Published online 2021 Mar 17. doi: 10.3390/ijerph18063099

PMCID: PMC8002654

52: The Impact of the Social Distancing Policy on COVID-19 Incidence Cases and Deaths in Iran from February 2020 to January 2021: Insights from an Interrupted Time Series Analysis

Mandana Saki, Mahboubeh Khaton Ghanbari, Meysam Behzadifar, Mohammad Hasan Imani-Nasab, Masoud Behzadifar, Samad Azari, Ahad Bakhtiari, Jianhong Wu, Nicola Luigi Bragazzi

Yale J Biol Med. 2021 Mar; 94(1): 13-21. Published online 2021 Mar 31. PMCID: PMC7995950

53: Acute Effects of Moderate versus High-Intensity Strength Exercise on Attention and Mood States in Female Physical Education Students

Hela Znazen, Maamer Slimani, Atyh Hadadi, Turki Alzahrani, David Tod, Nicola Luigi Bragazzi, Nizar Souissi Life (Basel) 2021 Sep; 11(9): 931. Published online 2021 Sep 7. doi: 10.3390/life11090931

PMCID: PMC8467463

54: COVID-19-Related Restrictions and Quarantine COVID-19: Effects on Cardiovascular and Yo-Yo Test Performance in Professional Soccer Players

Lucas de Albuquerque Freire, Márcio Tannure, Márcio Sampaio, Maamer Slimani, Hela Znazen, Nicola Luigi Bragazzi, Esteban Aedo-Muñoz, Dany Alexis Sobarzo Soto, Ciro José Brito, Bianca Miarka

Front Psychol. 2020; 11: 589543. Published online 2020 Dec 18. doi: 10.3389/fpsyg.2020.589543 PMCID: PMC7775546

55: Acute Effects of an "Energy Drink" on Short-Term Maximal Performance, Reaction Times, Psychological and Physiological Parameters: Insights from a Randomized Double-Blind, Placebo-Controlled, Counterbalanced Crossover Trial

western countries

PMCID: PMC8315811

Nutrients. 2019 May; 11(5): 992. Published online 2019 Apr 30. doi: 10.3390/nu11050992 PMCID: PMC6566184

56: The Effects of Physical Training on Quality of Life, Aerobic Capacity, and Cardiac Function in Older Patients With Heart Failure: A Meta-Analysis

Maamer Slimani, Rodrigo Ramirez-Campillo, Armin Paravlic, Lawrence D. Hayes, Nicola Luigi Bragazzi, Maha Sellami

Front Physiol. 2018; 9: 1564. Published online 2018 Nov 12. doi: 10.3389/fphys.2018.01564 PMCID: PMC6241114

57: The efficacy of Crocus sativus (Saffron) versus placebo and Fluoxetine in treating depression: a systematic review and meta-analysis

Mojtaba Khaksarian, Masoud Behzadifar, Meysam Behzadifar, Maryam Alipour, Firouzeh Jahanpanah, Tania Simona Re, Fabio Firenzuoli, Riccardo Zerbetto, Nicola Luigi Bragazzi

Psychol Res Behav Manag. 2019; 12: 297-305. Published online 2019 Apr 23. doi: 10.2147/PRBM.S199343 PMCID: PMC6503633

58: The role of the Primary Healthcare Network in Iran in hepatitis C virus elimination by 2030

Masoud Behzadifar, Hasan Abolghasem Gorji, Aziz Rezapour, Nicola Luigi Bragazzi, Seyed Moayed Alavian J Virus Erad. 2018 Jul; 4(3): 186-188. Published online 2018 Jul 1.

PMCID: PMC6038132

59: A Google Trends-based approach for monitoring NSSI

Nicola Luigi Bragazzi

Psychol Res Behav Manag. 2014; 7: 1-8. Published online 2013 Dec 13. doi: 10.2147/PRBM.S44084 PMCID: PMC3864993

60: The Association between Symptoms of Nomophobia, Insomnia and Food Addiction among Young Adults: Findings of an Exploratory Cross-Sectional Survey

Haitham Jahrami, Ammar Abdelaziz, Latifa Binsanad, Omar A. Alhaj, Mohammed Buheji, Nicola Luigi Bragazzi, Zahra Saif, Ahmed S. BaHammam, Michael V. Vitiello

Int J Environ Res Public Health. 2021 Jan; 18(2): 711. Published online 2021 Jan 15. doi: 10.3390/ijerph18020711 PMCID: PMC7830658

61: Knowledge, Attitude, and Practice Towards COVID-19 Among Pharmacists: A Cross-Sectional Study

Maha M AlRasheed, Amani H AlShahrani, Sara A AlMuhaini, Hadeel A AlKofide, Tariq M Alhawassi, Ahmed Aldemerdash, Omar A Alhaj, Nicola L Bragazzi, Haitham A Jahrami

Risk Manag Healthc Policy. 2021; 14: 3079-3090. Published online 2021 Jul 23. doi: 10.2147/RMHP.S317779

62: SleepOMICS: How Big Data Can Revolutionize Sleep Science

Nicola Luigi Bragazzi, Ottavia Guglielmi, Sergio Garbarino

Int J Environ Res Public Health. 2019 Jan; 16(2): 291. Published online 2019 Jan 21. doi: 10.3390/ijerph16020291 PMCID: PMC6351921

63: Effect of Taekwondo Practice on Cognitive Function in Adolescents with Attention Deficit Hyperactivity Disorder

Abdelmotaleb Kadri, Maamer Slimani, Nicola Luigi Bragazzi, David Tod, Fairouz Azaiez

Int J Environ Res Public Health. 2019 Jan; 16(2): 204. Published online 2019 Jan 12. doi: 10.3390/ijerph16020204 PMCID: PMC6352161

64: Illicit Drug Use in Canada and Implications for Suicidal Behaviors, and Household Food Insecurity: Findings from a Large, Nationally Representative Survey

Nicola Luigi Bragazzi, Dan Beamish, Jude Dzevela Kong, Jianhong Wu

Int J Environ Res Public Health. 2021 Jun; 18(12): 6425. Published online 2021 Jun 14. doi: 10.3390/ijerph18126425

PMCID: PMC8296225

65: Clonazepam monotherapy for treating people with newly diagnosed epilepsy

Francesco Brigo, Stanley C Igwe, Nicola Luigi Bragazzi, Simona Lattanzi, Cochrane Epilepsy Group

Cochrane Database Syst Rev. 2019 Nov; 2019(11): CD013028. Published online 2019 Nov 19. doi: 10.1002/14651858.CD013028.pub2

PMCID: PMC6863099

66: Psychoactive drug consumption among truck-drivers: a systematic review of the literature with meta- analysis and meta-regression

G. DINI, N.L. BRAGAZZI, A. MONTECUCCO, A. RAHMANI, P. DURANDO

J Prev Med Hyg. 2019 Jun; 60(2): E124-E139. Published online 2019 Jun 28. doi: 10.15167/2421- 4248/jpmh2019.60.2.1245

PMCID: PMC6614564

67: Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

Rola Khamisy-Farah, Leonardo B. Furstenau, Jude Dzevela Kong, Jianhong Wu, Nicola Luigi Bragazzi Int J Environ Res Public Health. 2021 May; 18(10): 5058. Published online 2021 May 11.

doi: 10.3390/ijerph18105058

PMCID: PMC8151939

68: Protocol of a scoping review assessing injury rates and their determinants among healthcare workers in

World Health Organization: health policy and historical implications

Nicola Luigi Bragazzi, Giulia Prasso, Tania Simona Re, Riccardo Zerbetto, Giovanni Del Puente

Nicola Luigi Bragazzi, Guglielmo Dini, Valentina Parodi, Carlo Blasi, Roberta Linares, Virginia Mortara, Alessandra Toletone, Francesca Maria Bersi, Beatrice D'Amico, Emanuela Massa, Alfredo Montecucco, Nicoletta Debarbieri, Paolo Durando

BMJ Open. 2019; 9(1): e023372. Published online 2019 Jan 30. doi: 10.1136/bmjopen-2018-023372 PMCID: PMC6359735

69: Sexual Activity before Sports Competition: A Systematic Review

Laura Stefani, Giorgio Galanti, Johnny Padulo, Nicola L. Bragazzi, Nicola Maffulli

Front Physiol. 2016; 7: 246. Published online 2016 Jun 21. doi: 10.3389/fphys.2016.00246 PMCID: PMC4914923

70: Trait Self-Control, Identified-Introjected Religiosity and Health-Related-Feelings in Healthy Muslims: A Structural Equation Model Analysis

Walid Briki, Asma Aloui, Nicola Luigi Bragazzi, Anis Chaouachi, Thomas Patrick, Karim Chamari

PLoS One. 2015; 10(5): e0126193. Published online 2015 May 11. doi: 10.1371/journal.pone.0126193 PMCID: PMC4427292

71: Effects of acculturation, coping strategies, locus of control, and self-efficacy on chronic pain: study of Chinese immigrant women in Italy - insights from a thematic field analysis

Tania Simona Re, Nicola Luigi Bragazzi, Anna Siri, César Cisneros Puebla, Susanne Friese, Mário Simões, Joël Candau, Hicham Khabbache

J Pain Res. 2017; 10: 1383-1390. Published online 2017 Jun 6. doi: 10.2147/JPR.S115449 PMCID: PMC5476582

72: Development and Validation of a Questionnaire investigating the Knowledge, Attitudes and Practices of Healthcare Workers in the Field of Anesthesiology concerning the Italian Law on Advance Healthcare Directives: a Pilot Study

Alessandro Bonsignore, Nicola Bragazzi, Chiara Basile, Paolo Pelosi, Angelo Gratarola, Giulia Bonatti, Nicolò Patroniti, Rosagemma Ciliberti

Acta Biomed. 2021; 92(4): e2021092. Published online 2021 Sep 2. doi: 10.23750/abm.v92i4.11314 PMCID: PMC8477106

73: Regular, Intense Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere Shortening and Adverse DNA Methylation Changes Over a Lifetime

Maha Sellami, Nicola Bragazzi, Mohammad Shoaib Prince, Joshua Denham, Mohamed Elrayess Front Genet. 2021; 12: 652497. Published online 2021 Aug 6. doi: 10.3389/fgene.2021.652497 PMCID: PMC8379006

74: Assessing Iran's health system according to the COVID-19 strategic preparedness and response plan of the

MAHBOUBEH KHATON GHANBARI, MASOUD BEHZADIFAR, AHAD BAKHTIARI, MEYSAM BEHZADIFAR, SAMAD AZARI, HASAN ABOLGHASEM GORJI, SAEED SHAHABI, MARIANO MARTINI, NICOLA LUIGI BRAGAZZI

J Prev Med Hyg. 2020 Dec; 61(4): E508-E519. Published online 2021 Jan 14. doi: 10.15167/2421- 4248/jpmh2020.61.4.1613

PMCID: PMC7888405

75: Mapping Research Trends of Universal Health Coverage From 1990 to 2019: Bibliometric Analysis

Mahboubeh Khaton Ghanbari, Masoud Behzadifar, Leila Doshmangir, Mariano Martini, Ahad Bakhtiari, Mahtab Alikhani, Nicola Luigi Bragazzi

JMIR Public Health Surveill. 2021 Jan; 7(1): e24569. Published online 2021 Jan 11. doi: 10.2196/24569 PMCID: PMC7834945

76: Knowledge, Attitudes, Practices (KAP) of Italian Occupational Physicians towards Tick Borne Encephalitis

Matteo Riccò, Giovanni Gualerzi, Silvia Ranzieri, Pietro Ferraro, Nicola Luigi Bragazzi

Trop Med Infect Dis. 2020 Sep; 5(3): 117. Published online 2020 Jul 16. doi: 10.3390/tropicalmed5030117 PMCID: PMC7559127

77: A 90 min Daytime Nap Opportunity Is Better Than 40 min for Cognitive and Physical Performance

Omar Boukhris, Khaled Trabelsi, Achraf Ammar, Raouf Abdessalem, Hsen Hsouna, Jordan M. Glenn, Nick Bott, Tarak Driss, Nizar Souissi, Omar Hammouda, Sergio Garbarino, Nicola Luigi Bragazzi, Hamdi Chtourou

Int J Environ Res Public Health. 2020 Jul; 17(13): 4650. Published online 2020 Jun 28. doi: 10.3390/ijerph17134650

PMCID: PMC7369743

78: Point-of-Care diagnostic of SARS-CoV-2: knowledge, attitudes, and perceptions (KAP) of medical workforce in Italy

Matteo Riccò, Pietro Ferraro, Giovanni Gualerzi, Silvia Ranzieri, Nicola Luigi Bragazzi, Federica Balzarini, Carlo Signorelli

Acta Biomed. 2020; 91(2): 57-67. Published online 2020 May 11. doi: 10.23750/abm.v91i2.9573 PMCID: PMC7569620

79: Pertussis immunization in healthcare workers working in pediatric settings: Knowledge, Attitudes and Practices (KAP) of Occupational Physicians. Preliminary results from a web-based survey (2017)

M. RICCò, L. VEZZOSI, G. GUALERZI, N.L. BRAGAZZI, F. BALZARINI

J Prev Med Hyg. 2020 Mar; 61(1): E66-E75. Published online 2020 Apr 2. doi: 10.15167/2421- 4248/jpmh2020.61.1.1155

PMCID: PMC7225653

80: A reliability and content analysis of Italian language anorexia nervosa-related websites

JMIR Ment Health. 2019 Apr; 6(4): e13154. Published online 2019 Apr 24. doi: 10.2196/13154

Risk Manag Healthc Policy. 2019; 12: 145-151. Published online 2019 Aug 1. doi: 10.2147/RMHP.S193088 PMCID: PMC6682172

81: Development and Preliminary Validation of the "Teacher of Physical Education Burnout Inventory" (TPEBI) in Arabic Language: Insights for Sports and Occupational Psychology

Nasr Chalghaf, Noomen Guelmami, Maamer Slimani, Giovanni Del Puente, Tania Simona Re, Riccardo Zerbetto, Juan José Maldonado Briegas, Ottavia Guglielmi, Sergio Garbarino, Fairouz Azaiez, Nicola Luigi Bragazzi

Front Psychol. 2019; 10: 456. Published online 2019 Apr 9. doi: 10.3389/fpsyg.2019.00456 PMCID: PMC6466693

82: Translation and Validation of the Nomophobia Questionnaire in the Italian Language: Exploratory Factor Analysis

Mohammad Adawi, Nicola Luigi Bragazzi, Lidia Argumosa-Villar, Joan Boada-Grau, Andreu Vigil-Colet, Caglar Yildirim, Giovanni Del Puente, Abdulla Watad

JMIR Mhealth Uhealth. 2018 Jan; 6(1): e24. Published online 2018 Jan 22. doi: 10.2196/mhealth.9186 PMCID: PMC5799721

83: Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects

Nadia Gulluni, Tania Re, Idalba Loiacono, Giovanni Lanzo, Luigi Gori, Claudio Macchi, Francesco Epifani, Nicola Bragazzi, Fabio Firenzuoli

Evid Based Complement Alternat Med. 2018; 2018: 1709182. Published online 2018 Jan 17. doi: 10.1155/2018/1709182

PMCID: PMC5822802

84: Antiepileptic drugs for the treatment of infants with severe myoclonic epilepsy

Cochrane Database Syst Rev. 2017 May; 2017(5): CD010483. Published online 2017 May 18. doi: 10.1002/14651858.CD010483.pub4

PMCID: PMC6481545

85: Assessing Ebola-related web search behaviour: insights and implications from an analytical study of Google Trends-based query volumes

Cristiano Alicino, Nicola Luigi Bragazzi, Valeria Faccio, Daniela Amicizia, Donatella Panatto, Roberto Gasparini, Giancarlo Icardi, Andrea Orsi

Infect Dis Poverty. 2015; 4: 54. Published online 2015 Dec 10. doi: 10.1186/s40249-015-0090-9 PMCID: PMC4674955

86: The Relationship Between Nomophobia and Maladaptive Coping Styles in a Sample of Italian Young Adults: Insights and Implications From a Cross-Sectional Study

Nicola Luigi Bragazzi, Tania Simona Re, Riccardo Zerbetto

PMCID: PMC6505371

87: From P0 to P6 medicine, a model of highly participatory, narrative, interactive, and "augmented"

medicine: some considerations on Salvatore Iaconesi's clinical story

Nicola Luigi Bragazzi

Patient Prefer Adherence. 2013; 7: 353-359. Published online 2013 Apr 24. doi: 10.2147/PPA.S38578 PMCID: PMC3640773

88: Commentary On: Self-Care Self-Efficacy, Religious Participation and Depression as Predictors of Post- Stroke Self-Care Among Underserved Ethnic Minorities

Nicola Luigi Bragazzi

Health Psychol Res. 2014 Apr 26; 2(2): 1641. Published online 2014 Sep 2. doi: 10.4081/hpr.2014.1641 PMCID: PMC4768553

89: Occupational Injuries and Use of Benzodiazepines: A Systematic Review and Metanalysis

Sergio Garbarino, Paola Lanteri, Nicola Luigi Bragazzi, Giovanni Gualerzi, Matteo Riccò

Front Hum Neurosci. 2021; 15: 629719. Published online 2021 May 13. doi: 10.3389/fnhum.2021.629719 PMCID: PMC8155305

90: Psychometric properties of the Brief Symptom Inventory in nomophobic subjects: insights from preliminary confirmatory factor, exploratory factor, and clustering analyses in a sample of healthy Italian volunteers

Mohammad Adawi, Riccardo Zerbetto, Tania Simona Re, Bishara Bisharat, Mahmud Mahamid, Howard Amital, Giovanni Del Puente, Nicola Luigi Bragazzi

Psychol Res Behav Manag. 2019; 12: 145-154. Published online 2019 Mar 12. doi: 10.2147/PRBM.S173282 PMCID: PMC6419603

91: Steroid hormones and psychological responses to soccer matches: Insights from a systematic review and meta-analysis

Maamer Slimani, Julien S. Baker, Foued Cheour, Lee Taylor, Nicola Luigi Bragazzi

PLoS One. 2017; 12(10): e0186100. Published online 2017 Oct 12. doi: 10.1371/journal.pone.0186100 PMCID: PMC5638322

92: Running Performance of High-Level Soccer Player Positions Induces Significant Muscle Damage and Fatigue Up to 24 h Postgame

Lucas Albuquerque Freire, Michele Andrade de Brito, Natã Sant'anna Esteves, Márcio Tannure, Maamer Slimani, Hela Znazen, Nicola Luigi Bragazzi, Ciro José Brito, Dany Alexis Sobarzo Soto, Daniel Gonçalves, Bianca Miarka

Front Psychol. 2021; 12: 708725. Published online 2021 Sep 14. doi: 10.3389/fpsyg.2021.708725 PMCID: PMC8477007

Study of Untimed Versus Timed Quizzing

93: A Thirty-Five-Minute Nap Improves Performance and Attention in the 5-m Shuttle Run Test during and outside Ramadan Observance

Hsen Hsouna, Omar Boukhris, Khaled Trabelsi, Raouf Abdessalem, Achraf Ammar, Jordan M. Glenn, Nick Bott, Nizar Souissi, Paola Lanteri, Sergio Garbarino, Nicola Luigi Bragazzi, Hamdi Chtourou

Sports (Basel) 2020 Jul; 8(7): 98. Published online 2020 Jul 11. doi: 10.3390/sports8070098 PMCID: PMC7404546

94: Effects of 25-Min Nap Opportunity during Ramadan Observance on the 5-m Shuttle Run Performance and the Perception of Fatigue in Physically Active Men

Hsen Hsouna, Omar Boukhris, Khaled Trabelsi, Raouf Abdessalem, Achraf Ammar, Khadijah Irandoust, Morteza Taheri, Nizar Souissi, Roy Jesse Shephard, Sergio Garbarino, Nicola Luigi Bragazzi, Hamdi Chtourou

Int J Environ Res Public Health. 2020 May; 17(9): 3135. Published online 2020 Apr 30. doi: 10.3390/ijerph17093135

PMCID: PMC7246774

95: Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes: A Pilot Study

Hanen Hafedh, Maamer Slimani, Bianca Miarka, Ramzi Bettayeb, Nicola Luigi Bragazzi

J Hum Kinet. 2019 Oct; 69: 169-178. Published online 2019 Oct 18. doi: 10.2478/hukin-2018-0097 PMCID: PMC6815083

96: Maximum Oxygen Uptake of Male Soccer Players According to their Competitive Level, Playing Position and Age Group: Implication from a Network Meta-Analysis

Maamer Slimani, Hela Znazen, Bianca Miarka, Nicola Luigi Bragazzi

J Hum Kinet. 2019 Mar; 66: 233-245. Published online 2019 Mar 27. doi: 10.2478/hukin-2018-0060 PMCID: PMC6458571

97: A preliminary validation of the Arabic version of the "Profile of Emotional Competence" questionnaire among Tunisian adolescent athletes and nonathletes: insights and implications for sports psychology

Hajer Aouani, Maamer Slimani, Nicola Luigi Bragazzi, Sabeur Hamrouni, Mohamed Elloumi

Psychol Res Behav Manag. 2019; 12: 155-167. Published online 2019 Mar 13. doi: 10.2147/PRBM.S188481 PMCID: PMC6422408

98: Eating disorders among Moroccan medical students: cognition and behavior

Nada Azzouzi, Samir Ahid, Nicola Luigi Bragazzi, Nabil Berhili, Chadya Aarab, Rachid Aalouane, Said Boujraf, Ismail Rammouz

Psychol Res Behav Manag. 2019; 12: 129-135. Published online 2019 Mar 11. doi: 10.2147/PRBM.S165114 PMCID: PMC6417001

99: Uncontrolled Web-Based Administration of Surveys on Factual Health-Related Knowledge: A Randomized

Alexander Domnich, Donatella Panatto, Alessio Signori, Nicola Luigi Bragazzi, Maria Luisa Cristina, Daniela Amicizia, Roberto Gasparini

J Med Internet Res. 2015 Apr; 17(4): e94. Published online 2015 Apr 13. doi: 10.2196/jmir.3734 PMCID: PMC4411364

100: Somatic perception, cultural differences and immigration: results from administration of the Modified Somatic Perception Questionnaire (MSPQ) to a sample of immigrants

Nicola Luigi Bragazzi, Giovanni Del Puente, Werner Maria Natta

Psychol Res Behav Manag. 2014; 7: 161-166. Published online 2014 Jun 12. doi: 10.2147/PRBM.S55393 PMCID: PMC4062560

101: Infodemiology and Infoveillance of Multiple Sclerosis in Italy

Nicola Luigi Bragazzi

Mult Scler Int. 2013; 2013: 924029. Published online 2013 Aug 20. doi: 10.1155/2013/924029 PMCID: PMC3762202

102: Znazen H, Slimani M, Bragazzi NL, Tod D. The Relationship between Cognitive Function, Lifestyle Behaviours and Perception of Stress during the COVID-19 Induced Confinement: Insights from Correlational and Mediation Analyses. Int J Environ Res Public Health. 2021 Mar 19;18(6):3194. doi: 10.3390/ijerph18063194. PMID: 33808777; PMCID: PMC8003540.

103: Yousfi N, Bragazzi NL, Briki W, Zmijewski P, Chamari K. The COVID-19 pandemic: how to maintain a healthy immune system during the lockdown - a multidisciplinary approach with special focus on athletes. Biol Sport. 2020 Sep;37(3):211-216. doi: 10.5114/biolsport.2020.95125. Epub 2020 May 19. PMID: 32879542; PMCID: PMC7433333.

104: Watad A, Bragazzi NL, Brigo F, Adawi M, Mahroum N, Comaneshter D, Amital D,

Cohen AD, Amital H. Epilepsy is not statistically associated with systemic sclerosis but significantly impacts on mortality: A real-world epidemiological survey-based study. Best Pract Res Clin Rheumatol. 2018 Oct;32(5):710-717. doi: 10.1016/j.berh.2019.02.013. Epub 2019 Mar 7. PMID: 31203929.

105: Watad A, Bragazzi NL, Adawi M, Aljadeff G, Amital H, Comaneshter D, Cohen AD,

Amital D. Anxiety disorder among rheumatoid arthritis patients: Insights from real-life data. J Affect Disord. 2017 Apr 15;213:30-34. doi: 10.1016/j.jad.2017.02.007. Epub 2017 Feb 6. PMID: 28188994.

Environ Res Public Health. 2021 Feb 22;18(4):2131. doi: 10.3390/ijerph18042131.

Professionals during the COVID-19 Pandemic: Comparing Mental Health

106: Trabelsi K, Ammar A, Masmoudi L, Boukhris O, Chtourou H, Bouaziz B, Brach M, Bentlage E, How D, Ahmed M, Mueller P, Mueller N, Hsouna H, Elghoul Y, Romdhani M, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna-Dos-Santos LJ, Taheri M, Irandoust K, Bragazzi NL, Strahler J, Washif JA, Andreeva A, Bailey SJ, Acton J, Mitchell E, Bott NT,

Gargouri F, Chaari L, Batatia H, Khoshnami SC, Samara E, Zisi V, Sankar P, Ahmed WN, Ali GM, Abdelkarim O, Jarraya M, Abed KE, Moalla W, Souissi N, Aloui A,

Souissi N, Gemert-Pijnen LV, Riemann BL, Riemann L, Delhey J, Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Dergaa I, Jmail

M, Barbosa F, Ferreira-Santos F, Šimunič B, Pišot R, Pišot S, Gaggioli A,

Steinacker J, Zmijewski P, Apfelbacher C, Glenn JM, Khacharem A, Clark CCT, Saad HB, Chamari K, Driss T, Hoekelmann A, On Behalf Of The Eclb-Covid Consortium. Sleep Quality and Physical Activity as Predictors of Mental Wellbeing Variance in Older Adults during COVID-19 Lockdown: ECLB COVID-19 International Online Survey. Int J Environ Res Public Health. 2021 Apr 19;18(8):4329. doi: 10.3390/ijerph18084329. PMID: 33921852; PMCID: PMC8073845.

107: Tourani S, Behzadifar M, Martini M, Aryankhesal A, Taheri Mirghaed M, Salemi M, Behzadifar M, Bragazzi NL. Health-related quality of life among healthy

elderly Iranians: a systematic review and meta-analysis of the literature.

Health Qual Life Outcomes. 2018 Jan 18;16(1):18. doi: 10.1186/s12955-018-0845-7. PMID: 29347951; PMCID: PMC5774099.

108: Slimani M, Znazen H, Bragazzi NL, Zguira MS, Tod D. The Effect of Mental Fatigue on Cognitive and Aerobic Performance in Adolescent Active Endurance Athletes: Insights from a Randomized Counterbalanced, Cross-Over Trial. J Clin Med. 2018 Dec 3;7(12):510. doi: 10.3390/jcm7120510. PMID: 30513903; PMCID: PMC6306934.

109: Slimani M, Bragazzi NL. Data concerning the impact of mental fatigue on vigor as measured with the Brunel Mood Scale (BRUMS) in both physically active and trained subjects: A mini meta-analysis. Data Brief. 2017 Jul 5;13:655-660. doi: 10.1016/j.dib.2017.06.056. PMID: 28725669; PMCID: PMC5503827.

110: Severo PP, Furstenau LB, Sott MK, Cossul D, Bender MS, Bragazzi NL. Thirty Years of Human Rights Study in the Web of Science Database (1990-2020). Int J

PMID: 33671671; PMCID: PMC7926733.

111: Saeedi Shahri SS, Ghashghaee A, Behzadifar M, Bragazzi NL, Behzadifar M, Mousavinejad N, Ghaemmohamadi MS, Ebadi F, Seyedin H. Depression among Iranian nurses: A systematic review and meta-analysis. Med J Islam Repub Iran. 2017 Dec 25;31:130. doi: 10.14196/mjiri.31.130. PMID: 29951430; PMCID: PMC6014776.

112: Magnavita N, Chirico F, Garbarino S, Bragazzi NL, Santacroce E, Zaffina S. SARS/MERS/SARS-CoV-2 Outbreaks and Burnout Syndrome among Healthcare Workers. An Umbrella Systematic Review. Int J Environ Res Public Health. 2021 Apr

20;18(8):4361. doi: 10.3390/ijerph18084361. PMID: 33924026; PMCID: PMC8072681.

113: Khabbache H, Jebbar A, Rania N, Doucet MC, Watfa AA, Candau J, Martini M, Siri A, Brigo F, Bragazzi NL. Empowering patients of a mental rehabilitation center in a low-resource context: a Moroccan experience as a case study. Psychol Res Behav Manag. 2017 Apr 10;10:103-108. doi: 10.2147/PRBM.S117456. PMID: 28435341; PMCID: PMC5391834.

114: H'mida C, Degrenne O, Souissi N, Rekik G, Trabelsi K, Jarraya M, Bragazzi NL, Khacharem A. Learning a Motor Skill from Video and Static Pictures in

Physical Education Students-Effects on Technical Performances, Motivation and Cognitive Load. Int J Environ Res Public Health. 2020 Dec 4;17(23):9067. doi: 10.3390/ijerph17239067. PMID: 33291727; PMCID: PMC7730545.

115: Guelmami N, Ben Khalifa M, Chalghaf N, Kong JD, Amayra T, Wu J, Azaiez F, Bragazzi NL. Development of the 12-Item Social Media Disinformation Scale and its Association With Social Media Addiction and Mental Health Related to COVID-19 in Tunisia: Survey-Based Pilot Case Study. JMIR Form Res. 2021 Jun 9;5(6):e27280. doi: 10.2196/27280. PMID: 34021742; PMCID: PMC8191730.

116: Ghram A, Bragazzi NL, Briki W, Jenab Y, Khaled M, Haddad M, Chamari K. COVID-19 Pandemic and Physical Exercise: Lessons Learnt for Confined Communities. Front Psychol. 2021 May 5;12:618585. doi: 10.3389/fpsyg.2021.618585. PMID: 34025498; PMCID: PMC8131539.

117: Franzoi IG, Granieri A, Sauta MD, Agnesone M, Gonella M, Cavallo R, Lochner P, Bragazzi NL, Naldi A. Anxiety, Post-Traumatic Stress, and Burnout in Health

Epilepsy in Hildegard of Bingen's writings: A comprehensive overview. Epilepsy

review and meta-analysis. BMC Endocr Disord. 2018 May 31;18(1):34. doi:

Professionals and Other Healthcare Workers. Healthcare (Basel). 2021 May 27;9(6):635. doi: 10.3390/healthcare9060635. PMID: 34071970; PMCID: PMC8229458.

118: Fekih S, Zguira MS, Koubaa A, Masmoudi L, Bragazzi NL, Jarraya M. Effects of Motor Mental Imagery Training on Tennis Service Performance during the Ramadan Fasting: a Randomized, Controlled Trial. Nutrients. 2020 Apr 9;12(4):1035. doi: 10.3390/nu12041035. PMID: 32283820; PMCID: PMC7231086.

119: Dahan S, Bragazzi NL, Yogev A, Bar-Gad M, Barak V, Amital H, Amital D. The relationship between serum cytokine levels and degree of psychosis in patients with schizophrenia. Psychiatry Res. 2018 Oct;268:467-472. doi: 10.1016/j.psychres.2018.07.041. Epub 2018 Jul 31. PMID: 30138859.

120: Chikha AB, Khacharem A, Trabelsi K, Bragazzi NL. The Effect of Spatial Ability in Learning From Static and Dynamic Visualizations: A Moderation Analysis in 6-Year-Old Children. Front Psychol. 2021 Jun 18;12:583968. doi: 10.3389/fpsyg.2021.583968. PMID: 34220599; PMCID: PMC8249578.

121: Cheour S, Cheour C, Bragazzi NL, Zou L, Paravlic AH, Slimani M, Cheour F.

Dose-Response Relationship between Endurance Training Prescription Variables and Increases in Aerobic Performance of Healthy and Unhealthy Middle and Very Old Individuals Aged 70 Years and Older: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Life (Basel). 2021 Feb 5;11(2):121. doi: 10.3390/life11020121. PMID: 33562480; PMCID: PMC7914556.

122: Chen W, Faris MAE, Bragazzi NL, AlGahtani HMS, Saif Z, Jahrami A, Shivappa N, Hebert JR, Jahrami H. Diet-Related Inflammation is Associated with Major Depressive Disorder in Bahraini Adults: Results of a Case-Control Study Using the Dietary Inflammatory Index. J Inflamm Res. 2021 Apr 15;14:1437-1445. doi: 10.2147/JIR.S306315. PMID: 33883920; PMCID: PMC8055288.

123: Chamari K, Roussi M, Bragazzi NL, Chaouachi A, Abdul RA. Optimizing training and competition during the month of Ramadan: Recommendations for a holistic and personalized approach for the fasting athletes. Tunis Med. 2019

Oct;97(10):1095-1103. PMID: 31691937.

124: Brigo F, Trinka E, Brigo B, Bragazzi NL, Ragnedda G, Nardone R, Martini M.

Behav. 2018 Mar;80:135-143. doi: 10.1016/j.yebeh.2017.10.002. Epub 2018 Feb 2.

PMID: 29414543.

125: Bragazzi NL, Watad A, Gizunterman A, McGonagle D, Mahagna H, Comaneshter D, Amital H, Cohen AD, Amital D. The burden of depression in systemic sclerosis patients: a nationwide population-based study. J Affect Disord. 2019 Jan

15;243:427-431. doi: 10.1016/j.jad.2018.09.075. Epub 2018 Sep 21. PMID:

30268959.

126: Bragazzi NL, Amital H, Adawi M, Brigo F, Watad S, Aljadeff G, Amital D, Watad A. What do people search online concerning the "elusive" fibromyalgia? Insights from a qualitative and quantitative analysis of Google Trends. Clin

Rheumatol. 2017 Aug;36(8):1873-1878. doi: 10.1007/s10067-017-3665-y. Epub 2017 May 1. PMID: 28462482.

127: Bragazzi NL, Pezzoni F, Del Puente G. Investigating Aggressive Styles and Defense Mechanisms in Bipolar Patients and in their Parents. Health Psychol Res. 2014 Oct 21;2(3):1546. doi: 10.4081/hpr.2014.1546. PMID: 26973942; PMCID: PMC4768587.

128: Bragazzi NL, Del Puente G. A proposal for including nomophobia in the new

DSM-V. Psychol Res Behav Manag. 2014 May 16;7:155-60. doi: 10.2147/PRBM.S41386. PMID: 24876797; PMCID: PMC4036142.

130: Bragazzi NL. Rethinking psychiatry with OMICS science in the age of personalized P5 medicine: ready for psychiatome? Philos Ethics Humanit Med. 2013 Jul 12;8:4. doi: 10.1186/1747-5341-8-4. PMID: 23849623; PMCID: PMC4120773.

131: Boukhris O, Trabelsi K, Shephard RJ, Hsouna H, Abdessalem R, Chtourou L, Ammar A, Bragazzi NL, Chtourou H. Sleep Patterns, Alertness, Dietary Intake, Muscle Soreness, Fatigue, and Mental Stress Recorded before, during and after Ramadan Observance. Sports (Basel). 2019 May 17;7(5):118. doi: 10.3390/sports7050118. PMID: 31109004; PMCID: PMC6571812.

132: Behzadifar M, Sohrabi R, Mohammadibakhsh R, Salemi M, Moghadam ST, Taheri Mirghaedm M, Behzadifar M, Baradaran HR, Bragazzi NL. General health status in Iranian diabetic patients assessed by short-form-36 questionnaire: a systematic

136: Adawi M, Amital H, Mahamid M, Amital D, Bisharat B, Mahroum N, Sharif K, Guy

10.1186/s12902-018-0262-2. PMID: 29855368; PMCID: PMC5984362.

133: Ammar A, Trabelsi K, Brach M, Chtourou H, Boukhris O, Masmoudi L, Bouaziz B, Bentlage E, How D, Ahmed M, Mueller P, Mueller N, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna L, Taheri M, Irandoust K, Khacharem A, Bragazzi NL, Strahler J, Adrian J, Andreeva A, Glenn

JM, Bott NT, Gargouri F, Chaari L, Batatia H, Khoshnami SC, Samara E, Zisi V,

Sankar P, Ahmed WN, Ali GM, Abdelkarim O, Jarraya M, Abed KE, Moalla W, Romdhani M, Aloui A, Souissi N, Lisette Van Gemert P, Riemann BL, Riemann L, Delhey J,

Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Jmail M, Barbosa F, Ferreira-Santos F, Šimunič B, Pišot R, Pišot S, Gaggioli A, Zmijewski P, Bailey SJ, Steinacker J, Chamari K, Driss T, Hoekelmann A. Effects of home confinement on mental health and lifestyle behaviours during the

COVID-19 outbreak: insights from the ECLB-COVID19 multicentre study. Biol Sport.

2021 Mar;38(1):9-21. doi: 10.5114/biolsport.2020.96857. Epub 2020 Aug 3. PMID:

33795912; PMCID: PMC7996377.

134: Ammar A, Mueller P, Trabelsi K, Chtourou H, Boukhris O, Masmoudi L, Bouaziz B, Brach M, Schmicker M, Bentlage E, How D, Ahmed M, Aloui A, Hammouda O, Paineiras-Domingos LL, Braakman-Jansen A, Wrede C, Bastoni S, Pernambuco CS, Mataruna-Dos-Santos LJ, Taheri M, Irandoust K, Khacharem A, Bragazzi NL, Adrian Washif J, Glenn JM, Bott NT, Gargouri F, Chaari L, Batatia H, Khoshnami SC,

Samara E, Zisi V, Sankar P, Ahmed WN, Ali GM, Abdelkarim O, Jarraya M, El Abed K, Romdhani M, Souissi N, Van Gemert-Pijnen L, Bailey SJ, Moalla W, Gómez-Raja J, Epstein M, Sanderman R, Schulz S, Jerg A, Al-Horani R, Mansi T, Jmail M, Barbosa F, Ferreira-Santos F, Šimunič B, Pišot R, Gaggioli A, Zmijewski P, Steinacker JM, Strahler J, Riemann L, Riemann BL, Mueller N, Chamari K, Driss T,

Hoekelmann A; ECLB-COVID19 Consortium. Psychological consequences of COVID-19 home confinement: The ECLB-COVID19 multicenter study. PLoS One. 2020 Nov

5;15(11):e0240204. doi: 10.1371/journal.pone.0240204. PMID: 33152030; PMCID: PMC7643949.

135: Alsalman A, Jahrami H, Mubarak H, Aljabal M, Abdulnabi M, Yusuf A, Ishaq A, Bragazzi N. The Psychological Impact of COVID-19 Pandemic on the population of Bahrain. Acta Biomed. 2020 Oct 26;91(4):e2020131. doi: 10.23750/abm.v91i4.10336. PMID: 33525217; PMCID: PMC7927468.

A, Adawi A, Mahagna H, Abu Much A, Watad S, Bragazzi NL, Watad A. Searching the Internet for psychiatric disorders among Arab and Jewish Israelis: insights from

a comprehensive infodemiological survey. PeerJ. 2018 Mar 14;6:e4507. doi: 10.7717/peerj.4507. PMID: 29576974; PMCID: PMC5857171.

TRANSHUMANGENEGeneral and Personalized DrugsValidation of genetic studiesLongevity enhancing techniquesSPECIALIZED STARTUPS

VIRUS VARIANT: Predictive medicinePredictive Virus MutationsValidation of existing Drugs and Vaccines Gene TherapiesSide effects genomic link

SPAIRT: Genetic evaluation of the athlete (both professional and amatorial). Possible pharmacological correction to lack in genetic mechanisms.Health Sphere: a device that keeps tracking of your genetic characteristics.ICUGENE: Genetic evaluation of admitted patients in ERs and ICUs.This evaluation determines the best set of drugs to apply, given the patient's genetic profile. Reduces collateral effects of multiple medications.METABOLAITE: Genetic cures and optimized drugs for various forms of diabetes

GENEPROTECTOR: Providing monitoring and cures to the deterioration of human DNA and tissues caused by radiations in Space and hazardous environments on Earth.

AMR Antimicrobial resistance: Assessing and preventing antibiotic resistance and proposing genetic solutions.

OPENAIMED: Educational Project to support TranshumanGene and the other Startups in their market expansion. The project aims to help disadvantaged students from all over the world learn new genetic techniques.

WHAT WE HAVE DONE SO FAR

*AI4Omics = Parallel OS for accelerating and normalizing processes and data analysis

*MetabolAite = Solution for diabetes cures

drugs and your genome: a reliable predictor of side effects

SARS CoV2 - Viruses - Bacteria: we predict them reliably and fight them efficiently (gene therapies) before they occur

Our Core business is:

Human genome and reliable prediction of drugs collateral effects

Elimination of the side effects of drugs for each person analyzed thanks to the computation of our system that allows you to choose the best drug (personalized medicine) exactly

Prediction and computation of lethal Virus/Bacterium new generated lethal sequence

Computation and reliable prediction of the lethal genomic sequences that are produced during replication of the virus/bacteria due to the mutations that occur and that our system calculates exactly

Creation of kits/swabs (patentable) to test for the presence of such lethal mutations

Creation of the best enzymes / MicroRNAs as vaccines (patentable) for the given sequences to immunize before getting infected and avoid suffering/death

What is a "Virus Variant"?V.V. is a predictive tool applied to the present virus strands and can tell you the most probable evolution of the virus itself. It's beneficial to produce efficient vaccines and test the existing ones

TranshumanGene is an AI division specialized in pharmaceutical "in silico" and "in vitro" R&D

DefinitionIn Silico: produced using computer modeling or computer simulation

Other critical applications are:ICU - Gene, a predictive tool that shows the effects of a vaccine on a specific subject or a homogeneous populationVaccines editing: the production in vitro of compounds that can be added to vaccines to make them more effective

VIRUS VARIANT

The predictive tool for better vaccines

Manaus population seemed to have reached herd immunity. However, given the massive transmission of the so-called Brazilian VOC, it was overwhelmed by the 2 and 3 COVID-19 waves.

Studying and modeling the mutational landscape of SARS-CoV-2 is of paramount importance given the urgent need to predict whether anti-COVID-19 vaccines will be effective or not on the so-called variants of concern (VOCs).

Including compounds able to fight future virus variants could end the pandemic.

TranshumanGene

Drugs under validation

Abstract

We are working on drugs validations; data will be released after journals publications

TransHumanGene has developed a predictive AI-based multi-factorial platform (Virus Variant) that computes all the possible mutations of genomes in viruses and other living forms.

Our priority is the generation of virtual molecules and microRNA essential for fighting viruses, validating vaccines, and foresee the effects on patients.

How VirusVariant works?

With the help of supercomputers, we calculate the most likely mutations of the virus. But this could be not so efficient. For this reason, we apply a reverse engineering process

Phase 1 Predicting Virus Mutations

Since the Antigens generated by the predicting process require an extensive screening assessing their toxicity, to be faster, we run a similar approach to determine the target Antigenes

Calculating Antigene variations

Actual Virus Antigene

Phase 2 Predicting Antigene Mutations (Reverse engineering)

Mutated Antigenes

Genetic/Proteomic database

Antigene validation

After the validation process, the resulting Antigenes will be associated with the predicted Viruses to find optimal matches

Transhumangene artificial intelligence-based biophysics

(artificial intelligence + computational biology = computational intelligence):

AI drugs from design in silico to in vitro to trials

What we have achieved

WHAT WE HAVE DONE SO FAR: IN SILICO TO IN VITRO

We have already successfully crystallized an insulin sequence, with an excellent resolution, one of the highest obtained results. This enables us to shed more light on the mechanisms of insulin action at a cellular and molecular level, studying its genetic variants and the primary pathogenic mechanisms leading to diabetes.

Systemic lupus erythematosus (SLE) is a complex, multi-factorial and multi-system autoimmune disease, which imposes a dramatically relevant clinical and societal burden. Steroids (including methylprednisolone) represent the gold-standard option in terms of pharmaceutical treatment, even though their administration can result in side-effects, also serious and life-threatening ones (like malignancies, immune dysregulation/impairment and metabolic syndrome). Molecules obtained and extracted from helminths can be as effective as steroids, if not even superior in terms of pharmacological efficacy, sparing steroid doses and curbing the likelihood of developing severe adverse events. Among the different molecules, tuftsin-phosphorylcholine appears to be particularly intriguing in that it finely tunes and modulates several immunological cascades and pathways. Utilizing a murine model of SLE nephritis (lupus-prone NZBxW/F1 mice) we were able to demonstrate the effectiveness of this novel helminth-based compound. Proteinuria grade, levels of anti-dsDNA autoantibodies and splenic cytokines (like pro-inflammatory cytokines interferon IFN-γ, interleukin IL-1β and IL-6) significantly decreased after administration of tuftsin-phosphorylcholine, whereas the concentration of anti-inflammatory cytokine IL-10 increased. Summarizing, tuftsin-phosphorylcholine seems to be a promising pharmacological treatment, even though the investigations conducted so far are preliminary and further research, including randomized clinical trials, is warranted

WHAT WE HAVE DONE SO FAR: IN SILICO TO IN VITRO TO TRIALS

AI4OMICS by TRANSHUMANGENE

A platform for geneticists,researchers, physicists, etc

Case Study: AFRICA

We are operating with patients of African origin."Africa needs not only its genetic library but also a calibrated set of genetic tools."

with TFRecordWriter(os.path.join(hparams.out_dir, _TRAIN)) as train_out, \

# We consider four possible scenarios for each read and adjust start/end

# indices to only include portions of read that overlap the window.

# 1) Read extends past 5' end of window

# 2) Read extends past 3' end of window

# 3) Read extends past 5' and 3' ends of window

# 4) Read falls entirely within window

if window_start == 0 and window_end != hparams.window_size:

read_start = pileup_range.start - read_position

read_end = None

if window_end == hparams.window_size and window_start != 0:

read_start = None

read_end = -1 * ((read_position + len(read_ints)) - pileup_range.end)

if window_start == 0 and window_end == hparams.window_size:

read_start = pileup_range.start - read_position

read_end = read_start + hparams.window_size

if window_start != 0 and window_end != hparams.window_size:

read_start = None

read_end = None

base_counts[window_start:window_end] += one_hot_read[read_start:read_end]

# Use fractions at each position instead of raw base counts.

base_counts /= np.expand_dims(np.sum(base_counts, axis=-1), -1)

# Save counts/fractions for each base separately.

features = example.features

for i in range(len(_ALLOWED_BASES)):

key = '%s_counts' % _ALLOWED_BASES[i]

features.feature[key].float_list.value.extend(list(base_counts[:, i]))

features.feature['ref_sequence'].int64_list.value.extend(

[_ALLOWED_BASES.index(base) for base in pileup_ref])

flank_size = hparams.window_size // 2

true_base = pileup_ref[flank_size]

features.feature['label'].int64_list.value.append(

_ALLOWED_BASES.index(true_base))

Optimization Tool for Omics

The Problem

A multitude of instruments is available in omics and genomics laboratories around the world and it's difficult to get uniformity in datasets. This is one of the biggest problems when it comes to applying AI to aggregate data or simply comparing aggregate data.

Data we are dealing with tend to be complex, big, and scattered. Consequently, solution patterns are often lost in multiple big foggy data clusters.

Most research procedures take a long time to complete, and the results are generally poorly organized. Hence, it takes extra time and resources to run formal algorithms.

The Solution - 1

There are three ways to solve this limiting factor:

- build a tool capable of harmonizing different data sets (third party management)

- create of a platform that allows scientists and researchers to enter and access data in a customized database that has already been structured

- create an AI-OS that mediates between these two approaches

AI4Omics BDM (Basic Data Management) features:

The software is essential in genetic laboratories for running harmonized data analysis.

AI4Omics, will provide the best quality in terms of:

- arranging genomic data,

- measuring or comparing DNA sequence format,

- gene expression,

- functional annotations,

- identifying genes (position, role, and expression domain)

def has_allowed_alignment(read):

"""Determines whether a read's CIGAR string has the allowed alignments."""

return all([c.operation in _ALLOWED_CIGAR_OPS for c in read.alignment.cigar])

def is_usable_example(reads, variants, ref_bases):

"""Determines whether a particular reference region and read can be used."""

# Discard examples with variants or no mapped reads.

if variants or not reads:

return False

# Use only examples where all reads have simple alignment and allowed bases.

for read in reads:

if not has_allowed_alignment(read):

return False

if any(base not in _ALLOWED_BASES for base in read.aligned_sequence):

return False

# Reference should only contain allowed bases.

if any(base not in _ALLOWED_BASES for base in ref_bases):

return False

return True

def has_allowed_alignment(read):

"""Determines whether a read's CIGAR string has the allowed alignments."""

return all([c.operation in _ALLOWED_CIGAR_OPS for c in read.alignment.cigar])

def is_usable_example(reads, variants, ref_bases):

"""Determines whether a particular reference region and read can be used."""

# Discard examples with variants or no mapped reads.

if variants or not reads:

return False

# Use only examples where all reads have simple alignment and allowed bases.

for read in reads:

if not has_allowed_alignment(read):

return False

if any(base not in _ALLOWED_BASES for base in read.aligned_sequence):

return False

# Reference should only contain allowed bases.

if any(base not in _ALLOWED_BASES for base in ref_bases):

return False

return True

The Solution - 2

The BDM embedded in AI4Omics is five to one hundred times more effective than typical parallel programs. We can eliminate errors and bad syncs with enhanced computational power for quicker autonomous algorithms.

In addition to this, we can organize and format heterogeneous data from a variety of sources and store them efficiently in several databases.

It represents a new step in parallel programming, deep learning, reinforcement learning, and machine learning providing new opportunities in science for;

- simulations,

- DNA sequencing,

- big data analysis,

- autonomously generated algorithms,

- precision and personalized medicine,

- disanguibication of different data,

- friendly interaction with different standards,

- integration with existing genomic apps to plan and execute complex tests.

Optimization Tool for Omics

Executive Summary

Ai4Omics' team has a long experience in parallel programming, deep learning, and genomics, creating new possibilities for achieving more significant results in science in general: simulations, DNA sequencing, big data

Ai4Omics has also developed a new Operating System for supercomputers and running on high-end laptops

This OS is called BDM (Basic Data Management)

Ai4Omics' BDM makes optimization of data complexity

class BaseHparams(object):

"""Default hyperparameters."""

def __init__(self,

total_epochs=100,

learning_rate=0.004,

l2=0.001,

batch_size=256,

window_size=21,

ref_path='hs37d5.fa.gz',

vcf_path='NA12878_calls.vcf.gz',

bam_path='NA12878_sliced.bam',

out_dir='examples',

model_dir='ngs_model',

log_dir='logs'):

self.total_epochs = total_epochs

self.learning_rate = learning_rate

self.l2 = l2

self.batch_size = batch_size

self.window_size = window_size

self.ref_path = ref_path

self.vcf_path = vcf_path

self.bam_path = bam_path

self.out_dir = out_dir

self.model_dir = model_dir

self.log_dir = log_dir

Extrapolation Tool for Omics

An essential feature of AI4Omics

The platform can run both on high-standard commercial computers and supercomputers. The operator inserts data into our cyber-secure environment, and AI4Omics generates machine learning algorithms that classify, organize the data, forming new data aggregates and structures. The second step is the "hunt" in these classes of patterns useful to create new therapies, drugs, and treatments. Once we have reached a sufficiently big cluster of data, we can abstract a virtually infinite number of artificial genomes, delivering preventive cures to the real world even before the critical point of illness has arisen. (Predictive Medicine)

Our platform would accelerate the research time for vaccines in the order x 12+

def generate_tfrecord_datasets(hparams):

"""Writes out TFRecords files for training, evaluation, and test datasets."""

if not os.path.exists(hparams.out_dir):

os.makedirs(hparams.out_dir)

# Fraction of examples in each dataset.

train_eval_test_split = [0.7, 0.2, 0.1]

num_train_examples = 0

num_eval_examples = 0

num_test_examples = 0

# Generate training, test, and evaluation examples.

with TFRecordWriter(os.path.join(hparams.out_dir, _TRAIN)) as train_out, \

TFRecordWriter(os.path.join(hparams.out_dir, _EVAL)) as eval_out, \

TFRecordWriter(os.path.join(hparams.out_dir, _TEST)) as test_out:

all_examples = make_ngs_examples(hparams)

for example in all_examples:

r = random.random()

if r < train_eval_test_split[0]:

train_out.write(proto=example)

num_train_examples += 1

elif r < train_eval_test_split[0] + train_eval_test_split[1]:

eval_out.write(proto=example)

num_eval_examples += 1

else:

test_out.write(proto=example)

num_test_examples += 1

print('# of training examples: %d' % num_train_examples)

print('# of evaluation examples: %d' % num_eval_examples)

print('# of test examples: %d' % num_test_examples)

def make_ngs_examples(hparams):

"""Generator function that yields training, evaluation and test examples."""

ref_reader = fasta.IndexedFastaReader(input_path=hparams.ref_path)

vcf_reader = vcf.VcfReader(input_path=hparams.vcf_path)

read_requirements = reads_pb2.ReadRequirements()

sam_reader = sam.SamReader(

input_path=hparams.bam_path, read_requirements=read_requirements)

Case Study: AFRICA

OMICA, a platform for genomic analysis

Applied to African descendent patients.

To face the21st century challenges

Health management Africa needs not only its

Own genetic library but also a calibrated set of genetic tools.

Lately, there have been lots of efforts in creating

libraries of genetic information about the population of Africa.